Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis.
Eun Hee KohJi Eun YoonMyoung Seok KoJaechan LeemJi-Young YunChung Hwan HongYun Kyung ChoSeung Eun LeeJung Eun JangJi Yeon BaekHyun Ju YooSu Jung KimChang Ohk SungJoon Seo LimWon-Il JeongSung Hoon BackIn-Jeoung BaekSandra TorresEstel Solsona-VilarrasaLaura Conde de la RosaCarmen Garcia-RuizAriel E FeldsteinJose C Fernandez-ChecaKi Up LeePublished in: Gut (2020)
SMS1 mediates hepatocyte pyroptosis through a novel DAG-PKCδ-NLRC4 axis and holds promise as a therapeutic target for NASH.