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Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers.

Farhia KabeerHoa TranMirela AndronescuGurdeep SinghHakwoo LeeSohrab SalehiBeixi WangJustina BieleJazmine BrimhallDavid GeeViviana CerdaCiara O'FlanaganTeresa AlgaraTakako KonoSean BeattyElena ZaikovaDaniel LaiEric LeeRichard MooreAndrew J Mungallnull nullMarc J WilliamsAndrew RothKieran R CampbellSohrab P ShahSamuel A J R Aparicio
Published in: Genome biology (2024)
Within a polyclonal tumor, clones with strong genotype-associated fitness under platinum remained fixed, minimizing transcriptional reversion upon drug withdrawal. Conversely, clones with weaker fitness display non-genomic transcriptional plasticity. This suggests CN-associated and CN-independent transcriptional states could both contribute to platinum resistance. The dominance of genomic or non-genomic mechanisms within polyclonal tumors has implications for drug sensitivity, restoration, and re-treatment strategies.
Keyphrases
  • drug induced
  • liver injury
  • single cell
  • copy number
  • gene expression
  • transcription factor
  • body composition
  • physical activity
  • rna seq
  • adverse drug
  • lymph node metastasis
  • heat shock
  • heat stress