Factors Influencing Plasma Concentrations of Valproic Acid in Pediatric Patients with Epilepsy and the Clinical Significance of CYP2C9 Genotypes in Personalized Valproic Acid Therapy.

Bingsuo MaKun YangXinping LiNing SuTing YuYan ZouXingmeng XuFei WangJingdong ChengZijun YanTong ChenLiangming Zhang

Published in: Therapeutic drug monitoring (2024)

Liver problems and mutations in the CYP2C9 gene increase VPA levels. This underscores the importance of considering these factors when prescribing VPA to children with epilepsy, thereby enhancing the safety and efficacy of the therapy.

Keyphrases

primary care
mental health
young adults
copy number
stem cells
genome wide
emergency department
gene expression
dna methylation
bone marrow
transcription factor
genome wide analysis