Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
Nabham RaiAkylbek SydykovBaktybek KojonazarovJochen WilhelmGrégoire ManaudSwathi VeerojuClemens RuppertFrédéric PerrosHossein Ardeschir GhofraniNorbert WeissmannHorst-Walter BirkRalph T SchermulyTatyana NovoyatlevaPublished in: The European respiratory journal (2022)
Our study demonstrates that targeting of Pin1 with small molecule inhibitor, Juglone, might be an attractive future therapeutic strategy for PAH and right heart disease secondary to PAH.