Role of the Hypoxia-Inducible Factor Pathway in Normal and Osteoarthritic Meniscus and in Mice after Destabilization of the Medial Meniscus.
Austin V StoneRichard F LoeserMichael F CallahanMargaret A McNultyDavid L LongRaghunatha R YammaniSara BeanKadie VandermanSusan ChubinskayaCristin M FergusonPublished in: Cartilage (2020)
The HIF pathway is likely not responsible for osteoarthritic changes in the human meniscus. Additionally, Epas1 insufficiency does not protect against osteoarthritis development in the mouse at early time points after DMM surgery. The HIF pathway may be more important for protection against catabolic stress.