Abnormal Histones Acetylation in Patients with Primary Sjögren's Syndrome.

Xiuying LvMi ZhouQi ZhangYan HeYing WangJingxiu XuanGuixiu ShiYan Li

Published in: Clinical rheumatology (2022)

• The mRNA expressions of p300, CREBBP and PCAF in PBMCs from pSS patients were decreased in comparison with HCs. • HAT activity and histone H3/H4 acetylation were reduced in PBMCs from pSS patients. • HAT activity was correlated with disease characters. • We show for the first time that the histone hypoacetylation may be involved in the pathogenesis of pSS.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
gene expression
dna methylation
case report
patient reported outcomes
systemic lupus erythematosus