A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.
Yuanbing JiangHyebin UhmFanny C IpLi OuyangRonnie M N LoElaine Y L ChengXiaoyun CaoClara M C TanBrian C H LawPaula Ortiz-RomeroAlbert Puig-PijoanAida Fernández-LebreroJosé ContadorKin Y MokJohn HardyTimothy C Y KwokVincent C T MokMarc Suárez-CalvetHenrik ZetterbergAmy K Y FuNancy Y IpPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
The authors developed a blood-based biomarker assay for Alzheimer's disease. The 21-protein assay classifies AD/MCI and indicates brain amyloid pathology. The 21-protein assay can simultaneously assess activities of five biological processes. Ethnic-specific dysregulations of biological processes in AD were revealed.