Loss of arginine vasopressin- and vasoactive intestinal polypeptide-containing neurons and glial cells in the suprachiasmatic nucleus of individuals with type 2 diabetes.

Rick HogenboomMartin J KalsbeekNikita L KorpelPaul de GoedeMarit KoenenRuud M BuijsJohannes A RomijnDick F SwaabAndries KalsbeekChun-Xia Yi

Published in: Diabetologia (2019)

Our data show that type 2 diabetes differentially affects the numbers of AVP- and VIP-expressing neurons and GFAP-ir astroglial cells in the SCN, each of which could affect the daily rhythmicity of the SCN biological clock machinery. Therefore, for effectively treating type 2 diabetes, lifestyle changes and/or medication to normalise central biological clock functioning might be helpful.

Keyphrases

type diabetes
induced apoptosis
cell cycle arrest
cardiovascular disease
spinal cord
physical activity
metabolic syndrome
glycemic control
nitric oxide
oxidative stress
healthcare
emergency department
cell death
spinal cord injury
weight loss
neuropathic pain
pi k akt
cell proliferation