Are we on track for diagnosing high-grade urothelial carcinoma with a minimum quantity of five malignant cells in lower tract specimens? Critical analysis of The Paris System Quantitation Criteria.

Published in: Cancer cytopathology (2023)

This study confirms that quantitation is an essential key to diagnose HGUC. The current TPS criterion of a minimum of five malignant cells in lower tract is robust with a ROHM of 100%. Diagnosing HGUC with less than five HGCs runs the risk of lowering the ROHM.

Keyphrases

induced apoptosis
high grade
cell cycle arrest
ms ms
mass spectrometry
liquid chromatography tandem mass spectrometry
endoplasmic reticulum stress
oxidative stress
low grade
signaling pathway
cell death
high resolution
tandem mass spectrometry