First-line chemotherapy in advanced intra-abdominal well-differentiated/dedifferentiated liposarcoma: An EORTC Soft Tissue and Bone Sarcoma Group retrospective analysis.
Silvia StacchiottiWinette T A van der GraafRoberta G SanfilippoSandrine I MarreaudWinan J van HoudtIan R JudsonAlessandro GronchiAndré B P van KuilenburgSaskia LitiereBernd KasperPublished in: Cancer (2022)
Cytotoxic chemotherapy, in particular anthracycline alone, had marginal activity in advanced IA-LPS. Ifosfamide-containing regimens showed higher activity, although it was not statistically significant and in a small number of cases, with the combination of doxorubicin and ifosfamide appearing to be the more active regimen available in fit patients. This series provides a benchmark for future trials on new drugs in WD/DD liposarcoma.