The impact of DRP1 on myocardial fibrosis in the obese minipig.
Ching-Yi ChenSin-Jin LiChia-Yu WangHarry J MersmannShih-Torng DingPublished in: European journal of clinical investigation (2020)
These results suggest that mitochondrial dynamics were linked to the progression of obesity-related cardiac injury. Inhibition of DRP1 after palmitate exposure in H9c2 cells resulted in improved ATP level and decreased apoptosis in vitro suggesting that mitochondrial fission serves a key role in progression of obesity-induced cardiac fibrosis.
Keyphrases
- weight loss
- oxidative stress
- cell cycle arrest
- metabolic syndrome
- left ventricular
- induced apoptosis
- insulin resistance
- type diabetes
- diabetic rats
- high fat diet induced
- cell death
- endoplasmic reticulum stress
- weight gain
- adipose tissue
- bariatric surgery
- drug induced
- heart failure
- obese patients
- signaling pathway
- skeletal muscle
- atrial fibrillation