Self-Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Applications.
Carmen C PirasClare S MahonDavid K SmithPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
This Full Paper reports the formation of silver (Ag) NPs within spatially resolved two-component hydrogel beads, which combine a low-molecular-weight gelator (LMWG) DBS-CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed through in situ reduction of AgI , with the resulting nanoparticle-loaded gels being characterised in detail. The antibacterial activity of the nanocomposite gel beads was tested against two drug-resistant bacterial strains, often associated with hospital-acquired infections: vancomycin-resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa (PA14), and the AgNP-loaded gels showed good antimicrobial properties against both types of bacteria. It is suggested that the gel bead format of these AgNP-loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing.
Keyphrases
- wound healing
- silver nanoparticles
- drug resistant
- drug delivery
- pseudomonas aeruginosa
- acinetobacter baumannii
- multidrug resistant
- staphylococcus aureus
- biofilm formation
- cystic fibrosis
- healthcare
- escherichia coli
- quantum dots
- gold nanoparticles
- deep brain stimulation
- adverse drug
- cancer therapy
- hyaluronic acid
- emergency department
- candida albicans
- simultaneous determination