Hippocampal mitophagy contributes to spatial memory via maintaining neurogenesis during the development of mice.
Le XuSaboor SaeedXinxu MaXufeng CenYifei SunYanan TianXuhong ZhangDanhua ZhangAnying TangHetong ZhouJianbo LaiHongguang XiaShaohua HuPublished in: CNS neuroscience & therapeutics (2024)
The observed decline in spatial memory in adult mice is associated with decreased mitophagy, which affects neurogenesis in the dentate gyrus. This underscores the therapeutic potential of enhancing mitophagy to counteract age- or disease-related cognitive decline.