The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression.

Anto Sam Crosslee Louis Sam TitusDharmendra SharmaMin Soo KimSantosh R D'Mello

Published in: BMC neuroscience (2019)

Our results suggest that Bdnf and Npas4 are transcriptional targets of Hdac3-mediated repression. HDAC3 inhibitors have been shown to protect against behavioral deficits and neuronal loss in mouse models of neurodegeneration and it is possible that these inhibitors work by upregulating neuroprotective genes like Bdnf and Npas4.

Keyphrases

histone deacetylase
stress induced
genome wide
transcription factor
gene expression
mouse model
genome wide identification
traumatic brain injury
cerebral ischemia
bioinformatics analysis
heat shock
dna methylation
brain injury
oxidative stress