Population Pharmacokinetics and Dosing Simulations of Ceftriaxone in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation (An ASAP ECMO Study).
Vesa ChengMohd H Abdul-AzizFay BurrowsHergen BuscherYoung-Jae ChoAmanda CorleyEileen GilderHyung-Sook KimSung Yoon LimShay McGuinnessRachael ParkeClaire ReynoldsSam RudhamSteven C WallisSusan A WelchJohn F FraserKiran ShekarJason Alexander Robertsnull nullPublished in: Clinical pharmacokinetics (2022)
Dosing recommendations for critically ill adult patients not on ECMO appear to be sufficient for patients on ECMO. Patients exhibiting augmented renal clearance (> 130 mL/min) or treatment of less susceptible pathogens may require higher doses, which requires further investigation.