Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis.

Lin GaoXiaowu DongWeijuan GongWei HuangJing XueQingtian ZhuNan MaWeiwei ChenXianghui FuXiang GaoZhaoyu LinYanbing DingJuanjuan ShiZhihui TongTingting LiuRajarshi MukherjeeRobert SuttonGuotao LuWei-Qin Li

Published in: British journal of pharmacology (2021)

This work demonstrates a critical role for NLRP3 inflammasome and GSDMD activation-mediated pyroptosis in acinar cells, linking pancreatic necrosis and systemic inflammation in AP. Targeting pyroptosis signalling pathways holds promise for specific AP therapy.

Keyphrases

nlrp inflammasome
transcription factor
induced apoptosis
single cell
cancer therapy
stem cells
big data
drug delivery
cell proliferation
artificial intelligence
pi k akt