Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations.
Rory Caitlin MonahanMichelle D van den BeukelNicole V BorggrevenRolf FronczekThomas Wj HuizingaMargreet KloppenburgGerda M Steup-BeekmanLeendert Adrianus TrouwPublished in: RMD open (2022)
In our NPSLE cohort, a subset of patients with SLE have anti-PTM antibodies against MAA, AGE and CarP modified proteins. Interestingly, anti-MAA and anti-CarP were more prevalent in NPSLE, a manifestation for which no biomarkers exist.