Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome.
Bethasiwi PRadha MadhyasthaHarishkumar MadhyasthaQueen Intan NurrahmahMasugi MaruyamaNakajima YHiroaki KataokaNozomi WatanabePublished in: Pharmacological reports : PR (2021)
Our current study suggests that carbachol induces NLRP3 inflammasome activation through mAChR and NF-ĸB, and that RA abolishes the inflammatory response. It reveals the potentials of co-administration of RA with cholinergic drugs to prevent inflammatory responses during cholinergic medications.