Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology.

Published in: BMC complementary medicine and therapies (2022)

Collectively, we combined network pharmacology and endothelial injury models to investigate the anti-AS mechanism of baicalin. The results demonstrate that baicalin may exert anti-oxidative stress effects by targeting NOX4, providing new mechanisms and insights to baicalin for the treatment of AS.

Keyphrases

endothelial cells
oxidative stress
type diabetes
signaling pathway
combination therapy
network analysis
vascular endothelial growth factor
heat shock protein