Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum.

Julia SchulzFelix BrandlMichel J Grothe Matthias KirschnerStefan KaiserAndre SchmidtStefan BorgwardtJosef PrillerChristian SorgMihai Avram

Published in: Schizophrenia bulletin (2023)

Results demonstrate complex (posterior vs. anterior BFCN) and non-linear (larger vs. lower VBM) differences in BFCN across the schizophrenia spectrum, which are specifically associated both with medication, including its anticholinergic burden, and cognitive symptoms. Data suggest an altered trajectory of BFCN integrity in schizophrenia, influenced by medication and relevant for cognitive symptoms.

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