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Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.

Modou JobeSchadrac C AgblaMarijana TodorcevicBakary DarboeEbrima DansoJean-Paul Pais de BarrosLaurent LagrostFredrik KarpeAndrew M Prentice
Published in: International journal of obesity (2005) (2022)
Raised levels of LPS and IL-6 in women with obesity-diabetes and evidence of macrophage activation in adipose tissue support the concept of metabolic endotoxemia-mediated inflammation, but we found no evidence for abnormal gut permeability or chylomicron-associated post-prandial translocation of LPS. Instead, the markedly lower EndoCAb IgM levels indicate a failure in sequestration and detoxification.
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