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A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV).

Rosita CappaiAlessandra FantasiaGuido CrisponiEugenio GarribbaMaria Amélia SantosValeria Marina Nurchi
Published in: Molecules (Basel, Switzerland) (2022)
The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of V IV O 2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1 H )-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric-spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.
Keyphrases
  • molecular dynamics
  • molecular dynamics simulations
  • ionic liquid
  • mass spectrometry
  • high resolution
  • clinical evaluation