Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.

Yi ZhangRoslyn TedjaMichael MillmanTerrence WongAlexandra FoxHussein ChehadeMeyer GershaterNicholas AdzibolosuRadhika GogoiMatthew AndersonThomas RutherfordZhenggang ZhangMichael ChoppGil MorAyesha B Alvero

Published in: bioRxiv : the preprint server for biology (2023)

In this study, we identified miR-421 as a specific signaling pathway in the ovarian tumor microenvironment that can downregulate CBX7 to induce epigenetic change in OC cells, which can drive disease progression. These findings suggest that targeting exosomal miR-421 may curtail ovarian cancer progression.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
signaling pathway
induced apoptosis
squamous cell carcinoma
pi k akt
small cell lung cancer
gene expression
cell cycle arrest
epithelial mesenchymal transition
risk assessment
oxidative stress
climate change