Colchicine improves CME-induced cardiac dysfunction and myocardial injury by inhibiting cardiomyocyte pyroptosis through the AMPK/SIRT1/NLRP3 signaling pathway.
Keyphrases
- signaling pathway
- nlrp inflammasome
- oxidative stress
- pi k akt
- high glucose
- left ventricular
- induced apoptosis
- diabetic rats
- epithelial mesenchymal transition
- skeletal muscle
- ischemia reperfusion injury
- coronary artery disease
- coronary artery
- protein kinase
- mouse model
- angiotensin ii
- heart failure
- drug induced
- cell proliferation
- atrial fibrillation
- aortic valve
- transcatheter aortic valve replacement