A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell.

Xiaohang WangWei LiJuan ChenSheng ZhaoShanhu QiuHan YinVladmir CarvalhoYunting ZhouRuifeng ShiJiannan HuShenyi LiMunire NijiatiZi-Lin Sun

Published in: Journal of diabetes research (2018)

Our study identified and validated the differences between PSC and ISC in genome-wide transcriptional scale, confirming the assumption that ISC and PSC are similar other than identical. Moreover, our data might be instrumental for further investigation of ISC and islet fibrosis, and some differential expressed genes may provide an insight into new therapeutic targets for type 2 diabetes.

Keyphrases

genome wide
single cell
type diabetes
cell therapy
gene expression
transcription factor
dna methylation
electronic health record
insulin resistance
adipose tissue
heat shock
big data
glycemic control
bone marrow
data analysis
bioinformatics analysis