Branched-chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes.
Juliette A de KlerkRoel BijkerkJoline Wilhelma Johanna BeulensAnton Jan van ZonneveldMirthe MuilwijkPeter P HarmsMarieke T BlomLeendert M 't HartRoderick C SliekerPublished in: Diabetes, obesity & metabolism (2024)
Our study shows the intricate relationship between plasma BCAA levels and CKD in individuals with type 2 diabetes. While an association exists, its manifestation varies based on disease status and BMI, with no definitive evidence supporting a causal link between BCAAs and prevalent CKD.