miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK.

Vladimir BezrookoveImran KhanAnukana BhattacharjeeJuifang FanRobyn JonesAnima SharmaMehdi NosratiPierre-Yves DesprezNathan SalomonisYihui ShiAltaf DarMohammed Kashani-Sabet

Published in: Journal of translational medicine (2024)

These studies identify miR-876 as a distinct tumor suppressor on 9p21 that is inactivated in melanoma and suggest miR-876 loss as an additional mechanism to activate ERK and the mitogen activated protein kinase (MAPK) pathway in melanoma. In addition, they suggest the therapeutic potential of combining miR-876 overexpression with BRAF inhibition as a rational therapeutic strategy for melanoma.

Keyphrases

cell proliferation
long non coding rna
signaling pathway
pi k akt
skin cancer
long noncoding rna
basal cell carcinoma
tyrosine kinase
case control