Genomics of ERBB2 -Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab.
Marla Lipsyc-SharfEsha JainLaura C CollinsShoshana M RosenbergKathryn J RuddyRulla M TamimiLidia SchapiraSteven E ComeJeffrey M PeppercornVirginia F BorgesEllen WarnerCraig SnowIan E KropDewey KimJakob H WeissJorge Gomez Tejeda ZanudoAnn H PartridgeNikhil WagleAdrienne G WaksPublished in: JCO precision oncology (2023)
CN changes were uncommon. We identified several genes warranting exploration as potential mechanisms of resistance to therapy in this population.
Keyphrases
- positive breast cancer
- epidermal growth factor receptor
- tyrosine kinase
- genome wide
- locally advanced
- single cell
- lymph node metastasis
- bioinformatics analysis
- human health
- metastatic breast cancer
- genome wide identification
- risk assessment
- stem cells
- gene expression
- rectal cancer
- radiation therapy
- transcription factor
- cell therapy
- climate change
- genome wide analysis
- chemotherapy induced