Acute Effect of Intravenous Sildenafil on Cerebral Blood Flow in Patients with Vasospasm After Subarachnoid Hemorrhage.
Rajat DharChad WashingtonMichael DiringerAllyson ZazuliaHussain JafriColin DerdeynGregory ZipfelPublished in: Neurocritical care (2017)
Infusion of sildenafil does not lead to a change in global or regional perfusion despite a significant reduction in cerebral perfusion pressure. While this could reflect the ineffectiveness of sildenafil-induced proximal vasodilatation to alter brain perfusion, it also suggests that cerebral autoregulatory function was preserved in this group. Future studies should assess whether sildenafil can restore or enhance autoregulation after SAH.
Keyphrases
- subarachnoid hemorrhage
- cerebral ischemia
- cerebral blood flow
- pulmonary hypertension
- brain injury
- pulmonary arterial hypertension
- contrast enhanced
- drug induced
- liver failure
- low dose
- magnetic resonance imaging
- respiratory failure
- diabetic rats
- high dose
- high glucose
- resting state
- magnetic resonance
- current status
- white matter
- blood brain barrier
- computed tomography
- hepatitis b virus
- case control
- functional connectivity
- endothelial cells
- aortic dissection
- intensive care unit
- mechanical ventilation