Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis.
Richard TaubertBastian EngelJana DiestelhorstKatharina L Hupa-BreierPatrick BehrendtNiklas T BaerleckenKurt-Wolfram SühsMaciej K JanikKalliopi ZachouMarcial SebodeChristoph SchrammMaría Carlota LondoñoSarah Habesnull nullYe H OoClaudine LalanneSimon PapeMaren SchubertMichael HustStefan DübelMario ThevisDanny JonigkJulia BeimdiekFalk F R BuettnerJoost P H DrenthLuigi MuratoriDavid H AdamsJessica K DysonAmédée RenandIsabel GrauperaAnsgar W LohseGeorge N DalekosPiotr MilkiewiczMartin StangelBenjamin MaasoumyTorsten WitteHeiner WedemeyerMichael P MannsElmar JaeckelPublished in: Hepatology (Baltimore, Md.) (2021)
pIgG could be used as a promising marker to improve the diagnostic workup of liver diseases with a higher specificity for AIH compared to conventional autoantibodies and a utility in autoantibody-negative AIH. Likewise, pIgG could be a major source of assay interference in untreated AIH.