Role of S100 and YKL40 on Intraventricular Cerebral Hemorrhages in the Preterm Infant and the Neuroprotective Role of miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 in Neonatal Mice with Nerve Injury.
Roghayeh IjabiZachary A KaminskyParisa RoozehdarJanat IjabiHemen Moradi-SardarehKing-Hwa LingNajmeh TehranianPublished in: Current medicinal chemistry (2023)
Our findings demonstrate that miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 injections prevent cerebral ischemia-induced brain damage in hypoxia mice by increasing HVCN1 and HIF-1a and decreasing S100b, which in turn lessens apoptosis and epilepsy in hypoxic mice.
Keyphrases
- cerebral ischemia
- cell proliferation
- long non coding rna
- long noncoding rna
- subarachnoid hemorrhage
- high fat diet induced
- endothelial cells
- blood brain barrier
- oxidative stress
- brain injury
- type diabetes
- cell death
- endoplasmic reticulum stress
- diabetic rats
- multiple sclerosis
- fluorescent probe
- preterm infants
- ultrasound guided