Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.

Laetitia L Lecante Sabrina Leverrier-Penna Thomas Gicquel Frank Giton Nathalie Costet Christèle Desdoits-Lethimonier Laurianne Lesné Bernard Fromenty Vincent Lavoue Antoine D Rolland Severine Mazaud-Guittot

Published in: The Journal of clinical endocrinology and metabolism (2022)

Our data indicate that APAP can impact first trimester human fetal ovarian development, especially during a 10- to 12-DW window of heightened sensitivity. Overall, APAP behaves as an endocrine disruptor in the fetal human ovary.

Keyphrases

endothelial cells
induced pluripotent stem cells
big data
liver injury