Relationship between degree of methylation of sperm long interspersed nuclear element-1 (LINE-1) gene and alteration of sperm parameters and age: a meta-regression analysis.

Andrea Crafa Claudia Leanza Rosita Angela Condorelli Sandro La Vignera Aldo Eugenio Calogero Rossella Cannarella

Published in: Journal of assisted reproduction and genetics (2023)

The results of this systematic review and meta-analysis do not suggest a determining role of sperm LINE1 gene methylation degree in patients with infertility and/or abnormal sperm parameters. Therefore, we do not suggest including LINE1 in the genetic panel of prospective studies aimed at identifying the most representative and cost-effective genes to be analyzed in couples undergoing ART cycles.

Keyphrases

genome wide
dna methylation
copy number
genome wide identification
gene expression
genome wide analysis
adipose tissue
metabolic syndrome
insulin resistance
polycystic ovary syndrome
data analysis