Tumor targeting with DGEA peptide ligands: a new aromatic peptide amphiphile for imaging cancers.

Fu-Kai ZhanJyun-Cheng LiuBill ChengYen-Chu LiuTsung-Sheng LaiHsin-Chieh Lin Mei-Yu Yeh

Published in: Chemical communications (Cambridge, England) (2019)

We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.

Keyphrases

living cells
high resolution
quantum dots
endothelial cells
induced apoptosis
fluorescence imaging
small molecule
cell cycle arrest
fluorescent probe
cancer therapy
mass spectrometry
oxidative stress
amino acid
signaling pathway
pi k akt