Vitamin D receptor methylation attenuates the association between physical activity and type 2 diabetes mellitus: A case-control study.

Songcheng YuYinhua FengChenling QuFei YuZhenxing Mao Chongjian WangWenjie LiXing Li

Published in: Journal of diabetes (2021)

The methylation status of the VDR promoter is associated with the secretion and sensitivity of insulin. VDR methylation attenuates the association between physical activity and T2DM, indicating that proactively physical activity may reduce the risk of T2DM, especially in people with low VDR methylation level.

Keyphrases

physical activity
dna methylation
genome wide
glycemic control
body mass index
type diabetes
gene expression
sleep quality
transcription factor
metabolic syndrome
cardiovascular risk factors
skeletal muscle