Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction.
Irene V van BloklandRoy OelenHilde E GrootJan-Walter BenjaminsKami PekayvazCorinna LosertViktoria KnottenbergMatthias HeinigLeo NicolaiKonstantin StarkPim van der HarstLude H FrankeMonique G P van der WijstPublished in: Circulation. Genomic and precision medicine (2024)
Our analyses revealed the immunologic pathways disturbed by STEMI, specifying affected cell types and disease stages. Additionally, we provide insights into patients expected to benefit most from anti-inflammatory treatments by identifying the genetic variants and disease stage at which these variants affect the outcome of these (drug-targeted) pathways. These findings advance our knowledge of the immune response post-STEMI and provide guidance for future therapeutic studies.
Keyphrases
- single cell
- immune response
- acute myocardial infarction
- percutaneous coronary intervention
- end stage renal disease
- rna seq
- anti inflammatory
- healthcare
- st elevation myocardial infarction
- ejection fraction
- newly diagnosed
- st segment elevation myocardial infarction
- chronic kidney disease
- high throughput
- dendritic cells
- cell therapy
- peritoneal dialysis
- stem cells
- toll like receptor
- coronary artery disease
- copy number
- current status
- inflammatory response
- patient reported outcomes
- bone marrow
- gene expression
- drug delivery
- mesenchymal stem cells
- case control