TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.

Harsh Nitin DongreRammah ElnourStian TornaasSiren FromreideLiv Cecilie Vestrheim ThomsenIngrid Benedicte Moss KolsethElisabeth Sivy NginamauAnne Christine JohannessenOlav Karsten VintermyrDaniela Elena CosteaLine Bjorge

Published in: Acta obstetricia et gynecologica Scandinavica (2023)

immunohistochemistry stratify VSCC cohort into three subtypes with TP53mutated patients having the worst prognosis. The detection of hrHPV mRNA by ISH was an independent predictor of increased survival. Thus, the combined detection of p53 and HPV mRNA might improve risk stratification in VSCC.

Keyphrases

prognostic factors
squamous cell carcinoma
end stage renal disease
chronic kidney disease
endothelial cells
newly diagnosed
loop mediated isothermal amplification
label free
real time pcr
peritoneal dialysis
high grade
induced pluripotent stem cells
locally advanced
free survival
patient reported