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Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism.
Zhoujun Liu
Yu Chen
Guofang Chen
Xiaodong Mao
Xiao Wei
Xingjia Li
Yijiao Xu
Fan Jiang
Kun Wang
Chao Liu
Published in:
Journal of diabetes research (2019)
Maternal hypothyroidism results in impaired pancreatic insulin synthesis and pancreatic cell proliferation in neonatal offspring and subsequent glucose intolerance in young offspring, which may be related to TRβ gene downregulation in the pancreas.
Keyphrases
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cell proliferation
high fat diet
type diabetes
middle aged
replacement therapy
cell cycle
insulin resistance
genome wide
signaling pathway
gene expression
blood glucose
pregnant women
blood pressure
glycemic control
transcription factor
weight loss
preterm birth