Transplantation of modified human bone marrow-derived stromal cells affords therapeutic effects on cerebral ischemia in rats.

Satoshi KawauchiTakao YasuharaKyohei KinSatoru YabunoChiaki SugaharaTakayuki NagaseKakeru HosomotoYosuke OkazakiYousuke TomitaMichiari UmakoshiTatsuya SasakiMasahiro KamedaCesario V BorlonganIsao Date

Published in: CNS neuroscience & therapeutics (2022)

SB623 cells with or without encapsulation showed therapeutic effects on ischemic stroke. Encapsulated SB623 cells showed enhanced neurogenesis and increased viability inside the capsules. This study reveals the mechanism of secretory function of transplanted SB623 cells, but not cell-cell interaction as primarily mediating the cells' functional benefits in ischemic stroke.

Keyphrases

induced apoptosis
cell cycle arrest
cerebral ischemia
single cell
stem cells
endothelial cells
oxidative stress
cell death
signaling pathway