Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma.
Matthias SchneiderLea VollmerAnna-Laura PotthoffVidhya M RaviBernd O EvertMohummad A RahmanShahin SarowarJan KueckelhausPaulina WillDavid ZurhorstKevin JosephJulian P MaierNicolas NeidertPaolo d'ErricoMelanie Meyer-LuehmannUlrich G HofmannAndreas DolfPaolo SalomoniErdem GüresirPer Ø EngerMartha ChekenyaTorsten PietschPatrick SchussOliver SchnellMike-Andrew WesthoffJürgen BeckHartmut VatterAndreas WahaUlrich HerrlingerDieter H HeilandPublished in: Neuro-oncology (2021)
The capacity of TM formation reflects transcriptional cellular heterogeneity. MFA effectively demolishes functional and morphological TM-based syncytial network architectures. These findings might pave the way to a clinical implementation of MFA as a TM-targeted therapeutic approach.