Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
Sinjini SikdarRoby JoehanesBonnie R JoubertCheng-Jian XuMarta Vives-UsanoFaisal I RezwanJanine F FelixJames M WardWeihua GuanRebecca C RichmondJennifer A BrodyLeanne K KüpersNour BaïzSiri E HåbergJennifer A SmithSarah E ReeseStella AslibekyanCathrine HoyoRadhika DhingraChristina A MarkunasTao XuLindsay M ReynoldsAllan C JustPooja R MandaviyaAkram GhantousBrian D BennettTianyuan WangThe Bios ConsortiumKelly M BakulskiErik MelenShanshan ZhaoJianping JinZdenko HercegJoyce van MeursJack A TaylorAndrea A BaccarelliSusan K MurphyYongmei LiuMonica Cheng Munthe-KaasIan J DearyWenche NystadMelanie WaldenbergerIsabella Annesi-MaesanoKaren ConneelyVincent Wv JaddoeDonna ArnettHarold SniederSharon Lr KardiaCaroline L ReltonKen K OngSusan EwartHortensia Moreno-MaciasIsabelle RomieuNona SotoodehniaMyriam FornageAlison Motsinger-ReifGerard H KoppelmanMariona BustamanteDaniel LevyStephanie J LondonPublished in: Epigenomics (2019)
Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
Keyphrases
- genome wide
- dna methylation
- pregnant women
- smoking cessation
- gestational age
- low birth weight
- cord blood
- birth weight
- gene expression
- preterm birth
- pregnancy outcomes
- healthcare
- systematic review
- preterm infants
- public health
- meta analyses
- high fat diet
- transcription factor
- adipose tissue
- insulin resistance
- skeletal muscle
- metabolic syndrome
- weight gain