Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.
Jian YangFantian ZengXiaofang LiChongZhao RanYun-Gen XuYuyan LiPublished in: Chemical communications (Cambridge, England) (2019)
In this report, we demonstrate a "V-shaped" NIRF probe PTO-29, which can monitor Aβ oligomers with high selectivity. PTO-29 was designed and showed significant response to Aβ oligomers in the fluorescence spectral tests and good properties. In vivo imaging results indicate that 4 month APP/PS1 AD mice have higher signals in the brain than age-matched wild type mice.
Keyphrases
- wild type
- fluorescent probe
- living cells
- high fat diet induced
- single molecule
- high resolution
- optical coherence tomography
- cognitive decline
- white matter
- magnetic resonance imaging
- magnetic resonance
- resting state
- computed tomography
- molecular dynamics simulations
- loop mediated isothermal amplification
- metabolic syndrome
- mass spectrometry
- insulin resistance
- brain injury
- crystal structure