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The Association Between Curvature and Rupture in a Murine Model of Abdominal Aortic Aneurysm and Dissection.

B A LaneM J UlineX WangT ShazlyN R VyavahareJ F Eberth
Published in: Experimental mechanics (2020)
We found the strongest associations between burst pressure and the maximum value of the first principal curvature (rho=-0.591, p-val=0.061), the maximum value of Mean curvature (rho=-0.545, p-val=0.087), and local values of Mean curvature at the burst location (rho=-0.864, p-val=0.001) with only the latter significant after Bonferroni correction. Additionally, the surface profile at failure was predominantly convex and hyperbolic (saddle-shaped) as indicated by a negative sign in the Gaussian curvature. Findings reiterate the importance of shape in experimental models of AAA.
Keyphrases
  • abdominal aortic aneurysm
  • protein kinase
  • high frequency
  • smooth muscle