Periocular Necrotizing Fasciitis Causing Posterior Orbitopathy and Vision Loss: How to Manage?
Bulent YaziciHuri SaburFatih TokaPublished in: Turkish journal of ophthalmology (2021)
Necrotizing fasciitis (NF) is a rare, rapidly progressive bacterial infection. Periorbital NF may spread from the eyelid into the posterior orbit. Extent of the infection is critical in planning surgical debridement. A diabetic 70-year-old man presented with a black wound and severe pain in the left periorbital area following a mild trauma. Clinical findings were consistent with NF involving the eyelids, temporal and malar regions. In addition, he had proptosis, diffuse ophthalmoplegia, and central retinal artery occlusion, suggesting deep orbital involvement. Computed tomography showed soft tissue abnormalities in the anterior orbit. The patient was successfully treated with subcutaneous debridement, antibiotherapy, and metabolic support. Periorbital NF may be complicated with posterior orbital cellulitis-like symptoms and retinal vascular occlusions, possibly because of remote vascular thrombi induced by bacterial toxins. This clinical manifestation should be distinguished from true bacterial invasion of the posterior orbit, which may require more aggressive surgical treatments such as exenteration.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- computed tomography
- nuclear factor
- oxidative stress
- optical coherence tomography
- diabetic retinopathy
- soft tissue
- inflammatory response
- multiple sclerosis
- type diabetes
- magnetic resonance imaging
- case report
- wound healing
- early onset
- low grade
- depressive symptoms
- sleep quality
- contrast enhanced
- neuropathic pain
- cell migration
- immune response
- physical activity
- drug induced
- dual energy