Hesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways.
Arshad Husain RahmaniAli Yousif BabikerShehwaz AnwarPublished in: Molecules (Basel, Switzerland) (2023)
Cancer represents one of the most frequent causes of death in the world. The current therapeutic options, including radiation therapy and chemotherapy, have various adverse effects on patients' health. In this vista, the bioactive ingredient of natural products plays a vital role in disease management via the inhibition and activation of biological processes such as oxidative stress, inflammation, and cell signaling molecules. Although natural products are not a substitute for medicine, they can be effective adjuvants or a type of supporting therapy. Hesperidin, a flavonoid commonly found in citrus fruits, with its potential antioxidant, anti-inflammatory, and hepatoprotective properties, and cardio-preventive factor for disease prevention, is well-known. Furthermore, its anticancer potential has been suggested to be a promising alternative in cancer treatment or management through the modulation of signal transduction pathways, which includes apoptosis, cell cycle, angiogenesis, ERK/MAPK, signal transducer, and the activator of transcription and other cell signaling molecules. Moreover, its role in the synergistic effects with anticancer drugs and other natural compounds has been described properly. The present article describes how hesperidin affects various cancers by modulating the various cell signaling pathways.
Keyphrases
- oxidative stress
- signaling pathway
- single cell
- cell cycle
- radiation therapy
- cell therapy
- cancer therapy
- anti inflammatory
- cell proliferation
- pi k akt
- induced apoptosis
- healthcare
- squamous cell carcinoma
- stem cells
- immune response
- transcription factor
- end stage renal disease
- mesenchymal stem cells
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- endothelial cells
- locally advanced
- health information
- climate change
- drug induced
- health promotion