The factors present in regenerating muscles impact bone marrow-derived mesenchymal stromal/stem cell fusion with myoblasts.

Paulina KasprzyckaKarolina ArchackaKamil KowalskiBartosz MierzejewskiMałgorzata ZimowskaIwona GrabowskaMariusz PiotrowskiMilena RafałkoAgata RyżkoAliksandra IrhashavaKamil SenderowskiMagdalena GołąbekWładysława StremińskaKatarzyna Jańczyk-IlachMarta KoblowskaRoksana Iwanicka-NowickaAnna FogtmanMirosław JanowskiPiotr WalczakMaria A CiemerychEdyta Brzoska

Published in: Stem cell research & therapy (2019)

To conclude, our study revealed that treatment with IGF-1, IL-4, IL-6, or SDF-1 affects BM-MSC interaction with myoblasts; however, it does not directly promote myogenic differentiation of these cells.

Keyphrases

stem cells
bone marrow
induced apoptosis
cell cycle arrest
skeletal muscle
mesenchymal stem cells
pi k akt
cell death
binding protein
combination therapy
cell therapy
cell proliferation