Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.

Vijay K Sonkar Alicia S EustesAzaj AhmedMelissa JensenMitali V SolankiJagadish SwamyRahul KumarTrevor P FidlerJon C D HoutmanBryan G Allen Douglas R Spitz E Dale Abel Sanjana Dayal

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Platelet mitochondrial ROS contributes to age-related thrombosis and endogenous SOD2 protects from platelet-dependent thrombin generation and thrombosis during aging.

Keyphrases

pulmonary embolism
amyotrophic lateral sclerosis
oxidative stress
dna damage
cell death
hydrogen peroxide
reactive oxygen species