Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis.

Haim LeibovitzhSun Ho LeeJuan Antonio Raygoza GarayOsvaldo Espin-GarciaMingyue XueAnna NeustaeterAshleigh GoethelHien Q HuynhAnne M GriffithsDan TurnerKaren L MadsenPaul MoayyediA Hillary SteinhartMark S SilverbergColette DeslandresAlain BittonDavid R MackKevan JacobsonMaria CinoGuy AumaisCharles N BernsteinRemo PanaccioneBatia WeissJonas HalfvarsonWei XuWilliams TurpinKenneth Croitorunull null

Published in: Gut (2023)

We identified serum proteomic signatures associated with future CD development, reflecting potential early biological processes of immune and barrier dysfunction.

Keyphrases

immune response
oxidative stress
genome wide
label free
current status
dendritic cells
cell therapy
toll like receptor
stem cells
risk assessment
gene expression
nk cells
drug induced