"Every Cloud Has a Silver Lining": How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It.
Martina CacciapuotiIlaria CaputoLucia Federica StefanelliPaul A DavisFederico NalessoLorenzo Arcangelo CalòPublished in: Clinics and practice (2024)
The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman's and Bartter's Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.
Keyphrases
- induced apoptosis
- coronavirus disease
- sars cov
- cell cycle arrest
- respiratory syndrome coronavirus
- end stage renal disease
- newly diagnosed
- genome wide
- ejection fraction
- chronic kidney disease
- prognostic factors
- oxidative stress
- signaling pathway
- amino acid
- dna methylation
- hypertrophic cardiomyopathy
- pi k akt
- binding protein
- silver nanoparticles