The Heart and Kidney: Abnormal Phosphate Homeostasis Is Associated With Atherosclerosis.
Rachel M HoldenMarie-France HétuTerry Y LiEmilie WardLaura E CoutureJulia E HerrErin ChristilawMichael A AdamsAmer M JohriPublished in: Journal of the Endocrine Society (2018)
Phosphate was independently associated with the severity of atherosclerosis in terms of plaque burden and composition. FGF-23 was associated with plaque calcification. These findings suggest that abnormal phosphate homeostasis may play an under-recognized but potentially modifiable role in cardiovascular disease.